Dostinex, prescribed for neurological disorders, may increase risk of valvular heart problems.

Dostinex is in the same class of prescription medications called 'ergot-derived receptor dopamine agonists' used in the treatment of Parkinson's disease and other neurological problems such as restless leg syndrome (RLS).

Two studies published by the New England Journal of Medicine in January 2007 indicated a statistically significant percentage of those who used Dostinex or Permax developed the potentially serious complication of valvular heart disease. Specifically, there was a significant increased risk of users having mitral, tricuspid, and aortic regurgitation, which could result in congestive heart failure and/or valvular heart disease. Valve regurgitation is a condition in which valves don't close tightly, allowing blood to flow backward across the valve. Symptoms include shortness of breath, fatigue and heart palpitations. In March 2007, the FDA announced a voluntary withdrawal of Permax products as a result of the link to a risk of serious damage to patients' heart valves. According to the release, the products being withdrawn are Permax, the trade name for pergolide marketed by Valeant Pharmaceuticals, and two generic versions of pergolide manufactured by Par and Teva.

Valvular heart disease is typically diagnosed by a painless and non-invasive test called an echocardiogram that uses sound waves to determine if the valves of the heart are functioning properly. In many cases, valvular heart disease does not immediately result in symptoms, so if you have taken either of these drugs, we would suggest that you speak to your physicians about having such a test, and about the nature of the risks associated with these two drugs . At this point in time, it appears that the only Parkinson's related drugs with a demonstrated association with valvular heart disease are Permax and Dostinex. The safer alternative to using these drugs are "non-ergot-derived dopamine receptor agonists".

Permax and Dostinex are chemically related to the diet drug 'Fen-phen', which was also related to the development of valvular heart disease and another very rare condition call Primary Pulmonary Hypertension (PPH). Do you have a Permax or Dostinex claim? If you or a loved one has suffered a serious heart injury involving valve damage or death as a result of Permax (pergolide) and/or Dostinex (cabergoline), you may be entitled to compensation for medical expenses, loss of wages, and pain and suffering.

Do not change medications without first consulting your doctor.